SPRING’s work in Ghana (2014–2017) aimed to improve the health of 1,000-day households with pregnant women and/or children under 2 years of age. Using evidence-based practices, SPRING developed a multi-sectoral program to reduce stunting and anemia in 15 districts of the Upper East and Northern regions of Ghana. The project linked the sectors of nutrition, WASH (water, sanitation, and hygiene), and agriculture, and employed social and behavior change communication approaches at household, community, and facility levels.